CD274 promotes cell cycle entry of leukemia-initiating cells through JNK/Cyclin D2 signaling.

Xia FangChiqi ChenFangzhen XiaZhuo YuYaping ZhangFeifei ZhangHao GuJiangbo WanXiaocui ZhangWei WengCheng Cheng ZhangGuo-Qiang ChenAibing LiangLi XieJunke Zheng

Published in: Journal of hematology & oncology (2016)

The surface immune molecule CD274 plays a critical role in the proliferation of LICs. The CD274/JNK/Cyclin D2 pathway promotes the cell cycle entry of LICs, which may serve as a novel therapeutic target for the treatment of leukemia.

Keyphrases

cell cycle
induced apoptosis
cell proliferation
signaling pathway
cell death
acute myeloid leukemia
bone marrow
cell cycle arrest
nk cells
endoplasmic reticulum stress
oxidative stress
smoking cessation