Disruption in the balance between apolipoprotein A-I and mast cell chymase in chronic hypersensitivity pneumonitis.
Yukihisa InoueTsukasa OkamotoTakayuki HondaYoshihisa NukuiTakumi AkashiTamiko TakemuraMinoru TozukaYasunari MiyazakiPublished in: Immunity, inflammation and disease (2020)
A decrease of apoA-I was associated with the pathogenesis of chronic HP in terms of pulmonary fibrosis and mast cell chymase attenuated the protective effect of apoA-I against pulmonary fibrosis. Furthermore, apoA-I could be a crucial molecule associated with lung fibrogenesis of HP.