Population pharmacokinetics of gabapentin in patients with neuropathic pain: Lack of effect of diabetes or glycaemic control.
Ana Carolina Conchon CostaJhohann Richard de Lima BenziPriscila Akemi YamamotoMaria Cristina Foss de FreitasFrancisco José Albuquerque de PaulaCleslei Fernando ZanelliGabriela Rocha LaurettiNatalia Valadares De MoraesPublished in: British journal of clinical pharmacology (2020)
This population pharmacokinetics model accurately estimated GBP concentrations in patients with neuropathic pain, using estimated glomerular filtrationrate as a covariate for total clearance. The distribution and excretion processes of GBP were not affected by hyperglycaemia or diabetes.