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Trastuzumab Deruxtecan in HER2-Positive Metastatic Breast Cancer Patients with Brain Metastases: A DESTINY-Breast01 Subgroup Analysis.

Guy JerusalemYeon Hee ParkSara Alsterlind HurvitzShanu ModiFabrice AndreIan E KropXavier GonzalezBenoit YouCristina SauraSung-Bae KimCynthia R OsborneRashmi K MurthyLorenzo GianniToshimi TakanoYali LiuJillian CathcartCaleb LeeChristophe Perrin
Published in: Cancer discovery (2022)
Advances in treating HER2-positive metastatic breast cancer have greatly improved patient outcomes, but intracranial progression remains an important risk for which few therapeutic options are currently available. T-DXd demonstrated durable efficacy in patients with stable, treated BMs. This article is highlighted in the In This Issue feature, p. 2711.
Keyphrases
  • metastatic breast cancer
  • brain metastases
  • small cell lung cancer
  • machine learning
  • deep learning
  • clinical trial
  • neural network
  • phase iii
  • double blind