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Effect of donor non-muscle myosin heavy chain (MYH9) gene polymorphisms on clinically relevant kidney allograft dysfunction.

Joanna PazikMonika OldakDominika OziębłoDominika Dęborska MaterkowskaAnna SadowskaJacek MalejczykMagdalena Durlik
Published in: BMC nephrology (2020)
Deceased donor kidneys of European descent harboring MYH9 SNPs rs3752462 T allele show significantly superior estimated filtration rate while those of rs136211 GG genotype excessive risk of proteinuria. These findings, if replicated, may further inform and improve individualization of allocation and treatment policies.
Keyphrases
  • hypertrophic cardiomyopathy
  • kidney transplantation
  • public health
  • skeletal muscle
  • oxidative stress
  • genome wide
  • weight gain
  • gene expression
  • left ventricular
  • heart failure
  • combination therapy
  • diabetic nephropathy