Preconception Genetic Carrier Screening for Miscarriage Risk Assessment: A Bioinformatic Approach to Identifying Candidate Lethal Genes and Variants.

Mona AminbeidokhtiJia-Hua QuShweta BelurHakan CakmakEleni JaswaRuth B LathiMarina SirotaMichael P SnyderSvetlana A YatsenkoAleksandar Rajkovic

Published in: medRxiv : the preprint server for health sciences (2023)

This study identified a set of genes and variants potentially associated with lethality across different ethnic backgrounds. The diversity of these genes amongst the various ethnic groups highlights the importance of designing a pan-ethnic PGCS panel comprising miscarriage-related genes.

Keyphrases

genome wide
copy number
risk assessment
bioinformatics analysis
genome wide identification
dna methylation
genome wide analysis
heavy metals
human health