Effects of a Global Rab27a Null Mutation on Murine PVAT and Cardiovascular Function.
Ashley SoucyChristian PottsAbigail KaijaAnne HarringtonMarissa McGilvreyGeorge L SutphinRon KorstanjeBenjamin TeroJacob SeekerIlka PinzCalvin VaryLarisa RyzhovaLucy LiawPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Global RAB27A loss impacted perivascular adipose tissue and thoracic aorta proteomic signatures, altered vasocontractile responses, and decreased left ventricular ejection fraction in mice.
Keyphrases
- ejection fraction
- aortic stenosis
- adipose tissue
- left ventricular
- aortic valve
- transcatheter aortic valve replacement
- insulin resistance
- spinal cord
- heart failure
- pulmonary artery
- high fat diet induced
- acute myocardial infarction
- high fat diet
- cardiac resynchronization therapy
- genome wide
- spinal cord injury
- type diabetes
- coronary artery disease
- pulmonary hypertension
- percutaneous coronary intervention