Eplerenone Prevents Cardiac Fibrosis by Inhibiting Angiogenesis in Unilateral Urinary Obstruction Rats.
Yi ChangYing BenHui LiYunzhao XiongGege ChenJuan HaoXuelian MaXiaomeng GaoPanpan QiangTatsuo ShimosawaXiangting WangFan YangQingyou XuPublished in: Journal of the renin-angiotensin-aldosterone system : JRAAS (2022)
/VEGFA signaling pathway, early treatment with the MR antagonist eplerenone in rats with UUO-induced CKD may significantly attenuate MR activation and cardiac fibrosis.
Keyphrases
- signaling pathway
- left ventricular
- contrast enhanced
- endothelial cells
- magnetic resonance
- high glucose
- chronic kidney disease
- pi k akt
- epithelial mesenchymal transition
- vascular endothelial growth factor
- liver fibrosis
- induced apoptosis
- mouse model
- computed tomography
- drug induced
- endoplasmic reticulum stress
- atrial fibrillation
- wound healing