Evaluation Criteria for Chromosome Instability Detection by FISH to Predict Malignant Progression in Premalignant Glottic Laryngeal Lesions.
Verona E BergshoeffMaschenka C A BalkenholAnnick HaesevoetsAndrea RulandMichelene N ChenaultRik C NelissenCarine J PeutzRuud ClarijsJeroen A W M Van der LaakRobert P TakesMichiel W M van den BrekelMarie-Louise F Van VelthuysenFrans C S RamaekersBernd KremerErnst-Jan Maria SpeelPublished in: Cancers (2022)
evaluation criteria for FISH 1c/7c based on PAN ≥ 10% provide the best prognostic information on the risk of malignant progression of premalignant laryngeal lesions as compared with criteria based on the CR. FISH 1c/7c detection can be applied in combination with histopathological assessment.