Mast cell-T cell axis alters development of colitis-dependent and colitis-independent colorectal tumours: potential for therapeutically targeting via mast cell inhibition.
Juliana Y SakitaJefferson Elias-OliveiraDaniela CarlosEmerson de Souza SantosLuciana Yamamoto AlmeidaTathiane M MaltaMariângela O BrunaldiSérgio de AlbuquerqueCleide Lúcia Araújo SilvaMarcus V AndradeVania L D BonatoSergio Britto GarciaFernando Queiroz CunhaGuilherme Cesar Martelossi CebinelliRonaldo B MartinsJason MatthewsLeandro ColliFrancis L MartinSergio A UyemuraVinicius KannenPublished in: Journal for immunotherapy of cancer (2022)
Therefore, we suggest that MCs have a dual role throughout CRC development and are potential druggable targets against this disease.