CX3CR1-microglia mediates neuroinflammation and blood pressure regulation in the nucleus tractus solitarii of fructose-induced hypertensive rats.
Chiu-Yi HoYu-Te LinHsin-Hung ChenWen-Yu HoGwo-Ching SunMichael HsiaoPei-Jung LuPei-Wen ChengChing-Jiunn TsengPublished in: Journal of neuroinflammation (2020)
We conclude that CX3CR1-microglia represses the nNOS signaling pathway and promotes chronic inflammation in fructose-induced hypertension. Collectively, our results reveal the role of chemokines such as IL-1β, IL-6, and TNF-α in NTS neuroinflammation with the involvement of FKN and CX3CR1.
Keyphrases
- blood pressure
- high glucose
- signaling pathway
- diabetic rats
- inflammatory response
- oxidative stress
- lipopolysaccharide induced
- drug induced
- rheumatoid arthritis
- neuropathic pain
- type diabetes
- endothelial cells
- epithelial mesenchymal transition
- pi k akt
- gene expression
- single cell
- spinal cord
- adipose tissue
- nitric oxide
- cell proliferation
- brain injury
- insulin resistance
- subarachnoid hemorrhage
- stress induced