Histone chaperone FACT complex mediates oxidative stress response to promote liver cancer progression.

Jialing ShenMengnuo ChenDerek LeeCheuk-Ting LawLai WeiFelice Ho-Ching TsangDon Wai-Ching ChinCarol Lai-Hung ChengJoyce Man-Fong LeeIrene Oi-Lin NgCarmen Chak-Lui WongChun Ming Wong

Published in: Gut (2019)

In conclusion, our findings demonstrated that FACT complex is essential for the expeditious HCC oxidative stress response and is a potential therapeutic target for HCC treatment.

Keyphrases

oxidative stress
dna methylation
dna damage
ischemia reperfusion injury
gene expression
induced apoptosis
human health
climate change
diabetic rats
replacement therapy
endoplasmic reticulum