CD24 identifies nucleus pulposus progenitors/notochordal cells for disc regeneration.

Zhuochao LiuZhiyong ZhengJin QiJun WangQi ZhouFangqiong HuJing LiangChangwei LiWeibin ZhangXingkai Zhang

Published in: Journal of biological engineering (2018)

Our studies identify that CD24-positive NP cells are the resident progenitor/notochordal cells in disc regeneration and elucidate a crucial role of HIF-1α-Notch1 pathway in the phenotypic maintenance of CD24-positive NP cells.

Keyphrases

induced apoptosis
cell cycle arrest
stem cells
signaling pathway
cell proliferation