Low Dose Berberine Suppresses Cholangiocarcinoma Cell Progression as a Multi-Kinase Inhibitor.
Sumalee ObchoeiMarutpong DetaryaPiyanard BoonnatePaksiree SaranarukKulthida VaeteewoottacharnPanupong MahalapbutrSeiji OkadaSopit WongkhamPublished in: Asian Pacific journal of cancer prevention : APJCP (2022)
Low dose of BBR suppresses EMT and thus aggressiveness of CCA cells, in part by its multi-kinase inhibitor property on EGFR and its downstream pathways. BBR might be beneficial for therapy of human CCA.
Keyphrases
- low dose
- induced apoptosis
- signaling pathway
- high dose
- endothelial cells
- small cell lung cancer
- epithelial mesenchymal transition
- cell therapy
- cell cycle arrest
- single cell
- epidermal growth factor receptor
- induced pluripotent stem cells
- tyrosine kinase
- stem cells
- oxidative stress
- cell proliferation
- pi k akt
- bone marrow
- replacement therapy