Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption.

Rui ZhangYun LiuYan ChenQian LiCharles MarshallTing WuGang HuMing Xiao

Published in: CNS neuroscience & therapeutics (2019)

These results demonstrate that AQP4-mediated glymphatic clearance ameliorates brain impairments caused by abnormal accumulation of metabolic wastes following chronic SD, thus serving as a potential target for sleep-related disorders.

Keyphrases

mouse model
resting state
white matter
sleep quality
physical activity
functional connectivity
cerebral ischemia
drug induced
risk assessment
human health
anaerobic digestion
heavy metals
sewage sludge