Cognitive resilience/reserve: Myth or reality? A review of definitions and measurement methods.

Chiara PappaletteraClaudia CarrariniFrancesca MiragliaFabrizio VecchioPaolo M Rossini

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

This review examines the concept of cognitive reserve in brain aging, in the context of dementia and its early stages. We have evaluated the methods commonly used to define and measure cognitive reserve. Sociobehavioral proxies, neuroimaging, and electrophysiological and genetic measures are discussed. The review emphasizes the importance of further research to identify and enhance this protective factor for cognitive preservation.

Keyphrases

mild cognitive impairment
gene expression
multiple sclerosis
genome wide
depressive symptoms
cognitive impairment
copy number
functional connectivity