Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort.

Iván Galván-FemeníaMireia Obón-SantacanaDavid PiñeyroMarta Guindo-MartinezXavier DuranAnna CarrerasRaquel PluvinetJuan VelascoLaia RamosSusanna AussóJ M MercaderLluis PuigManuel PeruchoDavid TorrentsVictor MorenoLauro SumoyRafael de Cid

Published in: Journal of medical genetics (2018)

Considering multiple-related genetic phenotypes improve associated genome signal detection. These results indicate the potential value of data-driven multivariate phenotyping for genetic studies in large population-based cohorts to contribute to knowledge of complex traits.

Keyphrases

genome wide
dna methylation
copy number
endothelial cells
healthcare
body composition
high throughput
loop mediated isothermal amplification
gene expression
risk assessment
real time pcr
human health
transcription factor
quantum dots
genome wide identification