Extracorporeal Shock Wave Therapy Improves Nontraumatic Knee Contracture in a Rat Model.
Yang LiQing LiaoJing ZengZhenzhen ZhangBaojian LiZiyi LuoXiang XiaoGang LiuPublished in: Clinical orthopaedics and related research (2023)
This work suggests ESWT may be worth exploring in preliminary research in humans to determine whether it may be a treatment option for patients with nontraumatic knee contractures. If the mechanism of ESWT can be confirmed in humans, ESWT might be a therapy for diseases involved in the TGF-β1/SMADs signaling pathway, such as hypertroic scarring and scleroderma.
Keyphrases
- total knee arthroplasty
- signaling pathway
- transforming growth factor
- knee osteoarthritis
- epithelial mesenchymal transition
- systemic sclerosis
- anterior cruciate ligament
- anterior cruciate ligament reconstruction
- pi k akt
- stem cells
- induced apoptosis
- rheumatoid arthritis
- oxidative stress
- replacement therapy
- bone marrow
- endoplasmic reticulum stress
- smoking cessation