Impaired biogenesis of basic proteins impacts multiple hallmarks of the aging brain.
Domenico Di FraiaAntonio MarinoJae Ho LeeErika Kelmer SacramentoMario BaumgartSara BagnoliPedro Tomaz da SilvaAmit Kumar SahuGiacomo SianoMax TiessenEva Terzibasi-TozziniJulien GagneurJudith FrydmanAlessandro CellerinoAlessandro OriPublished in: bioRxiv : the preprint server for biology (2024)
Translation pausing reshapes the aging brain proteome, revealing vulnerabilities in the biogenesis of nucleic-acid protein.