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Impaired biogenesis of basic proteins impacts multiple hallmarks of the aging brain.

Domenico Di FraiaAntonio MarinoJae Ho LeeErika Kelmer SacramentoMario BaumgartSara BagnoliPedro Tomaz da SilvaAmit Kumar SahuGiacomo SianoMax TiessenEva Terzibasi-TozziniJulien GagneurJudith FrydmanAlessandro CellerinoAlessandro Ori
Published in: bioRxiv : the preprint server for biology (2024)
Translation pausing reshapes the aging brain proteome, revealing vulnerabilities in the biogenesis of nucleic-acid protein.
Keyphrases
  • nucleic acid
  • resting state
  • white matter
  • functional connectivity
  • cerebral ischemia
  • multiple sclerosis
  • protein protein
  • amino acid
  • blood brain barrier
  • brain injury