Is patient exposure preapproval and postapproval a determinant of the timing and frequency of occurrence of safety issues?
Alexandra C PacurariuChristina E HoevePeter ArlettGeorgy GenovJim SlatteryMiriam C J M SturkenboomSabine M J M StrausPublished in: Pharmacoepidemiology and drug safety (2017)
Our results suggest that postapproval exposure influences the detection of safety issues.