Mapping potential pathways from polygenic liability through brain structure to psychological problems across the transition to adolescence.
Benjamin B LaheyE Leighton DurhamSarah J BrislinPeter B BarrDanielle M DickTyler M MooreBrandon L PierceLin TongGabrielle E ReimannHee Jung JeongRandolph M DupontAntonia N KaczkurkinPublished in: Journal of child psychology and psychiatry, and allied disciplines (2024)
Across the adolescent transition, the extPGS predicted both variance specific to conduct problems and variance shared by all measured problems. The extPGS also was associated with TGMV, which robustly predicted conduct problems. Statistical mediation analyses suggested the hypothesis that polygenic variation influences individual differences in brain development that are related to the likelihood of conduct problems during the adolescent transition, justifying new research to test this causal hypothesis.