fNIRS as a biomarker for individuals with subjective memory complaints and MCI.

Tsz Lok Lee Lizhi Guo Agnes Sui Yin Chan

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

Only amnestic mild cognitive impairment (aMCI), but not non-amnestic MCI, showed lower oxyhemoglobin (HbO) than normal individuals. Reduced HbO was observed in those with severe subjective memory complaints (SMCs) compared to normal cognition (NC), mild, and moderate SMCs. Functional near-infrared spectroscopy measures were associated with performance in memory assessments. Prefrontal hemodynamics could distinguish aMCI and severe SMC from NC.

Keyphrases

mild cognitive impairment
working memory
cognitive decline
early onset
sleep quality
high intensity
functional connectivity
multiple sclerosis
drug induced
transcranial magnetic stimulation
high frequency