The impact of extended treatment with artemether-lumefantrine on antimalarial exposure and reinfection risks in Ugandan children with uncomplicated malaria: A randomized controlled trial.

Meghan E WhalenRichard KajubiJustin GoodwinFrancis OrukanMcKenzie ColtLiusheng HuangKacey RichardsKaicheng WangFangyong LiNorah MwebazaFrancesca T AweekaSunil Parikh

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)

Extending the duration of AL was safe and significantly enhanced overall drug exposure in young children but did not lead to significant reductions in recurrent parasitemia risk in our high transmission setting. However, day 7 levels were strongly predictive of recurrent parasitemia risk and those in the lowest weight-band were at higher risk of underdosing with the standard 3-day regimen.

Keyphrases

plasmodium falciparum
body mass index
physical activity
emergency department
weight loss
human health
climate change
urinary tract infection
replacement therapy
smoking cessation