Possible involvement of CXCR3-CXCR6 + CD4 + T cells in Langerhans cell histiocytosis.

Akemi TokutsuYosuke OkadaAkira KurozumiKenichi TanakaSatoshi KuboYoshiya Tanaka

Published in: Journal of bone and mineral metabolism (2023)

We found abundant peripheral blood-activated Th17 cells and high percentages of IL-17-producing cells in osteolytic bone lesions in LCH. This finding, together with the decrease in peripheral blood-activated Th17 cells following chemotherapy, suggests the potential involvement of activated Th17 cells in LCH-related osteolysis.

Keyphrases

induced apoptosis
peripheral blood
cell cycle arrest
endoplasmic reticulum stress
stem cells
squamous cell carcinoma
radiation therapy
single cell
mesenchymal stem cells