Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model.
Yaping WangYu ShiYongquan HuangWei LiuGuiyuan CaiShimin HuangYanyan ZengSiqiang RenHongrui ZhanWen WuPublished in: Journal of neuroinflammation (2020)
Taken together, these data reveal that resveratrol relieves neuropathic pain through suppressing microglia-mediated neuroinflammation via regulating the TREM2-autophagy axis in SNI rats.
Keyphrases
- neuropathic pain
- signaling pathway
- inflammatory response
- spinal cord
- spinal cord injury
- lipopolysaccharide induced
- cell death
- endoplasmic reticulum stress
- lps induced
- oxidative stress
- traumatic brain injury
- electronic health record
- genome wide
- toll like receptor
- single cell
- big data
- cognitive impairment
- gene expression
- dna methylation
- immune response
- brain injury
- blood brain barrier