Methyl donor supplementation reduces phospho-Tau, Fyn and demethylated PP2A levels, and mitigates learning and motor deficits in a mouse model of tauopathy.

Our findings provide the first experimental evidence that boosting one-carbon metabolism with L-methylfolate, choline and betaine can mitigate key pathological, learning and motor deficits in a tauopathy mouse model. They give support to using a combination of methyl donors as a preventive or disease-modifying strategy for tauopathies.