Synaptic gene expression changes in frontotemporal dementia due to the MAPT 10 + 16 mutation.

Owen DandoRobert McGeachanJamie McQueenPaul BaxterNathan RockleyHannah McAlisterAdharsh PrasadXin HeDeclan KingJamie RosePhillip B JonesJane TullochSiddharthan ChandranColin SmithGiles HardinghamTara L Spires-Jones

Published in: Neuropathology and applied neurobiology (2024)

Our data indicate that synaptic pathology likely contributes to pathogenesis in FTDtau10 + 16 caused by the MAPT 10 + 16 mutation.

Keyphrases

gene expression
prefrontal cortex
dna methylation
electronic health record
big data
artificial intelligence