Discovery of new pesticide candidates from nature: design, synthesis and bioactivity research of rutaecarpine derivatives.

Miao-Miao ChenXin GuoTai-Qing LiXing-Xing HeDe-Ya WenXing-Chen HangAi-Dang LuZheng-Hong ZhouQing-Min WangZi-Wen Wang

Published in: Pest management science (2024)

The natural product rutaecarpine and its derivatives were synthesized, and evaluated for their anti-TMV and fungicidal activities. Compounds 5n and 5p with good activities emerged as new antiviral and anti-fungal candidates, respectively. This study provides important information for the research and development of the novel antiviral and fungicidal agents based on rutaecarpine derivatives. © 2024 Society of Chemical Industry.

Keyphrases

structure activity relationship
small molecule
risk assessment
health information
social media
cell wall