Brain Virome in Neurodegenerative Disorders: Insights from Transcriptomic Data Analysis.
Brinda BalakrishnanSiva Santhiya ArulAarti RavindranSangita VenkataramanPublished in: ACS chemical neuroscience (2023)
Neurodegenerative disorders (NDs) are chronic ailments of the central nervous system that gradually deteriorate the structures and functions of neurons. The etiologies of NDs include genetic factors, aging, infections, starvation, brain trauma, and spinal cord injury, among others. However, it is unclear whether viral infections impact the prognosis of NDs or contribute to their development. Hence, we investigated the prevalence of neurotropic viruses in brain samples by using transcriptomic data. A total of 1635 viral isolates with complete genomic information was used to investigate the incidence of 18 distinct viruses across 129 data sets from healthy and ND subjects. Our findings support the evidence pointing to the existence of a brain virome where certain viruses co-occur. We further hypothesize that distinct virome profiles are linked to different forms of NDs.
Keyphrases
- data analysis
- resting state
- white matter
- spinal cord injury
- functional connectivity
- risk factors
- spinal cord
- sars cov
- cerebral ischemia
- electronic health record
- single cell
- big data
- genetic diversity
- rna seq
- high resolution
- healthcare
- dna methylation
- machine learning
- social media
- mass spectrometry
- health information
- atomic force microscopy