Zika vector competence data reveals risks of outbreaks: the contribution of the European ZIKAlliance project.
Thomas ObadiaGladys Gutierrez-BugalloVeasna DuongAna I NuñezRosilainy Surubi FernandesBasile KamgangLiza HeryYann GomardSandra R AbboDavy JiolleUros GlavinicMyrielle Dupont-RouzeyrolCélestine M AtyameNicolas PocquetSebastien BoyerCatherine DaugaMarie VazeilleAndré YébakimaMichael T WhiteConstantianus J M KoenraadtPatrick MavinguiAnubis Vega-RuaEva VeronesiGorben P PijlmanChristophe PaupyNúria BusquetsRicardo Lourenço de OliveiraXavier Nicolas de LamballerieAnna-Bella FaillouxPublished in: Nature communications (2022)
First identified in 1947, Zika virus took roughly 70 years to cause a pandemic unusually associated with virus-induced brain damage in newborns. Zika virus is transmitted by mosquitoes, mainly Aedes aegypti, and secondarily, Aedes albopictus, both colonizing a large strip encompassing tropical and temperate regions. As part of the international project ZIKAlliance initiated in 2016, 50 mosquito populations from six species collected in 12 countries were experimentally infected with different Zika viruses. Here, we show that Ae. aegypti is mainly responsible for Zika virus transmission having the highest susceptibility to viral infections. Other species play a secondary role in transmission while Culex mosquitoes are largely non-susceptible. Zika strain is expected to significantly modulate transmission efficiency with African strains being more likely to cause an outbreak. As the distribution of Ae. aegypti will doubtless expand with climate change and without new marketed vaccines, all the ingredients are in place to relive a new pandemic of Zika.
Keyphrases
- aedes aegypti
- zika virus
- climate change
- dengue virus
- sars cov
- coronavirus disease
- quality improvement
- genetic diversity
- human health
- escherichia coli
- electronic health record
- oxidative stress
- white matter
- diabetic rats
- resting state
- big data
- cord blood
- gestational age
- brain injury
- deep learning
- endothelial cells
- stress induced