The homodimer interfaces of costimulatory receptors B7 and CD28 control their engagement and pro-inflammatory signaling.

Andrey PopugailoZiv RotfogelMichal LevyOrli TurgemanDalia HillmanRevital LevyGila AradTomer ShpilkaRaymond Kaempfer

Published in: Journal of biomedical science (2023)

Our results reveal that the B7 and CD28 homodimer interfaces each control B7/CD28 costimulatory receptor engagement and highlight the protective potential against cytokine storm of attenuating, yet not ablating, pro-inflammatory signaling via these receptor domains.

Keyphrases

social media
nk cells
genome wide
binding protein
dna methylation
gene expression
human health