Bone marrow mesenchymal stem cell-derived exosomal miR-221-3p promotes angiogenesis and wound healing in diabetes via the downregulation of forkhead box P1.

Zhi-Yang QiuWei-Cheng XuZun-Hong Liang

Published in: Diabetic medicine : a journal of the British Diabetic Association (2024)

Exosomal miR-221-3p isolated from BMSCs promoted angiogenesis in diabetic wounds through the mediation of the FOXP1/SPRY1 axis. Furthermore, the findings of this study can provide new insights into probing strategies against diabetes.

Keyphrases

wound healing
bone marrow
type diabetes
mesenchymal stem cells
cardiovascular disease
transcription factor
glycemic control
endothelial cells
regulatory t cells
cell proliferation
signaling pathway
single molecule
stem cells
binding protein
skeletal muscle
dendritic cells