Manganese-catalyzed hydroarylation of multiple bonds.

Transition metal-catalyzed C-H activation has become a promising strategy in organic synthesis due to its improved atom-, step- and resource economy. Considering the Earth's abundance, economic benefits, and low toxicity, 3d metal catalysts for C-H activation have received a significant focus. In particular, organometallic manganese-catalyzed C-H activation has proven to be versatile and suitable for a wide range of transformations such as C-H addition to π-components, arylation, alkylation, alkynylation, amination, and many more. Among them, manganese-catalyzed C-H addition to C-C and C-heteroatom multiple bonds exhibited unique and promising reactivity to construct a wide range of complex organic molecules. In this review, we highlight the developments in the field of manganese-catalyzed hydroarylation of multiple bonds via C-H activation with a range of applications until August 2022.