Tumor necrosis factor-inducible gene 6 protein and its derived peptide ameliorate liver fibrosis by repressing CD44 activation in mice with alcohol-related liver disease.

Jinsol HanChanbin LeeHayeong JeongSeunghee JeonMyunggyo LeeHaeseung LeeYung Hyun ChoiYoungmi Jung

Published in: Journal of biomedical science (2024)

These results demonstrate that TSG-6 attenuates alcohol-induced liver damage and fibrosis by blocking CD44 cleavage to CD44ICD and suggest that TSG-6 and TSG-6-mimicking peptide could be used as therapeutics for ALD with fibrosis.

Keyphrases

liver fibrosis
rheumatoid arthritis
alcohol consumption
genome wide
copy number
high glucose
gene expression
diabetic rats
dna methylation
binding protein
high fat diet induced
stress induced