SPG11-related parkinsonism: Clinical profile, molecular imaging and l-dopa response.
Ingrid FaberAlberto Rolim Muro MartinezCarlos Roberto MartinsMaidane Luise MaiaJuliana Pasquotto SouzaCharles Marques LourençoWilson MarquesCeleste MontecchianiAntonio OrlacchioJose Luiz PedrosoOrlando Graziani Povoas BarsottiniCelso Darío RamosÍscia Lopes-CendesJoseph H FriedmanBárbara Juarez AmorimMarcondes Cavalcante FrançaPublished in: Movement disorders : official journal of the Movement Disorder Society (2018)
Disruption of presynaptic dopaminergic pathways is a widespread phenomenon in patients with SPG11 mutations, even in the absence of parkinsonism. Unresponsiveness to treatment could be related to postsynaptic damage that needs to be further investigated.