Impact of maternal infection on outcomes in extremely preterm infants.

Christina L HerreraPriyanka S KadariJessica E PruszynskiImran Mir

Published in: Pediatric research (2023)

Maternal infection was not associated with neurodevelopmental impairment (NDI) or death at 2 years of age in extremely preterm (EPT) infants. This is reassuring support that mechanisms at the maternal-fetal interface largely protect the EPT infant. However, pathologic findings of acute histologic chorioamnionitis were associated with NDI and death at 2 years of age. Further work should investigate the differential influence of infection and immune response with acute histologic chorioamnionitis on pathology as relates to outcomes in EPT infants.

Keyphrases

preterm infants
immune response
liver failure
birth weight
low birth weight
pregnancy outcomes
respiratory failure
gestational age
type diabetes
aortic dissection
intensive care unit
metabolic syndrome
toll like receptor
physical activity
skeletal muscle