Wnt/β-Catenin Signaling in Neural Stem Cell Homeostasis and Neurological Diseases.
Juanmei GaoYuan LiaoMengsheng QiuWanhua ShenPublished in: The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry (2020)
Neural stem/progenitor cells (NSCs) maintain the ability of self-renewal and differentiation and compose the complex nervous system. Wnt signaling is thought to control the balance of NSC proliferation and differentiation via the transcriptional coactivator β-catenin during brain development and adult tissue homeostasis. Disruption of Wnt signaling may result in developmental defects and neurological diseases. Here, we summarize recent findings of the roles of Wnt/β-catenin signaling components in NSC homeostasis for the regulation of functional brain circuits. We also suggest that the potential role of Wnt/β-catenin signaling might lead to new therapeutic strategies for neurological diseases, including, but not limited to, spinal cord injury, Alzheimer's disease, Parkinson's disease, and depression.
Keyphrases
- stem cells
- cell proliferation
- spinal cord injury
- cerebral ischemia
- resting state
- white matter
- gene expression
- functional connectivity
- depressive symptoms
- transcription factor
- subarachnoid hemorrhage
- spinal cord
- multiple sclerosis
- epithelial mesenchymal transition
- cognitive decline
- neuropathic pain
- young adults
- physical activity
- climate change
- bone marrow
- heat shock
- heat shock protein