Synthesis, In Silico and Pharmacological Evaluation of New Thiazolidine-4-Carboxylic Acid Derivatives Against Ethanol-Induced Neurodegeneration and Memory Impairment.
Shagufta NazLina Tariq Al KuryHumaira NadeemFawad Ali ShahAman UllahRehan Zafar ParachaMuhammad ImranShupeng LiPublished in: Journal of inflammation research (2022)
Overall, our results revealed that these derivatives may be beneficial in reducing neuroinflammation by acting on different stages of inflammation. Moreover, P8 and P9 treatment attenuated the neuroinflammation, oxidative stress, and memory impairment caused by ethanol.
Keyphrases
- oxidative stress
- diabetic rats
- traumatic brain injury
- working memory
- lipopolysaccharide induced
- lps induced
- cognitive impairment
- dna damage
- high glucose
- cerebral ischemia
- ischemia reperfusion injury
- structure activity relationship
- molecular docking
- induced apoptosis
- single cell
- endothelial cells
- heat shock protein
- smoking cessation