Assessing neuraxial microstructural changes in a transgenic mouse model of early stage Amyotrophic Lateral Sclerosis by ultra-high field MRI and diffusion tensor metrics.
Rodolfo Gabriel GattoCarina WeissmannManish AminAriel FinkielszteinRonen SumaginThomas H MareciOsvaldo Daniel UchitelRichard L MaginPublished in: Animal models and experimental medicine (2020)
Changes in diffusion tensor shape were observed in this animal model at the early, nonsymptomatic stages of ALS. Further studies of CL, CP, and CS as imaging biomarkers should be undertaken to refine this neuroimaging tool for future clinical use in the detection of the early stages of ALS.