Developmental origins of exceptional health and survival: A four-generation family cohort study.
Matthew Thomas KeysDorthe Almind PedersenPernille Stemann LarsenAlexander KulminskiMary F FeitosaMary WojczynskiMichael ProvinceKaare ChristensenPublished in: medRxiv : the preprint server for health sciences (2024)
Previous researched has demonstrated potent health and survival advantages across three-generations in longevity-enriched families. However, the survival advantage associated with familial longevity may manifest earlier in life than previously thought.In our study of third and fourth-generation descendants of longevity-enriched sibships, we observed a broad infant health and survival advantage reflected by protection against a diverse range of adverse birth outcomes.These advantages were strongly attenuated between the third and fourth generations, independent of otherwise stable socioeconomic and behavioural parental advantages, as well as maternal and paternal lines of transmission.Our findings suggest that familial aggregation of exceptional health and survival may have early life developmental components and triangulate to implicate heritable genetic and or epigenetic factors in their transmission.
Keyphrases
- public health
- healthcare
- mental health
- free survival
- early life
- health information
- gene expression
- dna methylation
- health promotion
- emergency department
- type diabetes
- risk assessment
- human health
- metabolic syndrome
- early onset
- physical activity
- copy number
- drosophila melanogaster
- climate change
- skeletal muscle
- weight loss
- pregnancy outcomes