Effects of Modulation of the Hedgehog and Notch Signaling Pathways on Osteoblast Differentiation Induced by Titanium with Nanotopography.
Paola Gomes SouzaLeticia Faustino AdolphoHelena Bacha LopesDenise WeffortAlann Thaffarell Portilho SouzaFabiola Singaretti OliveiraAdalberto Luiz RosaAdalberto Luiz RosaPublished in: Journal of functional biomaterials (2023)
Our results indicated that the Hedgehog and Notch signalling pathways drive osteoblast/Ti interactions more intensely on nanotopography. We also demonstrated that combining Hedgehog activation with Notch inhibition exhibits synergistic effects on osteoblast differentiation, especially on Ti-Nano. The uncovering of these cellular mechanisms contributes to create strategies to control the process of osseointegration based on the development of nanostructured surfaces.