Hepatotoxicity of aflatoxin B1 and its oxidative effects in wood dust Egyptian exposed workers.
Amal Saad-HusseinEman M ShahyWeam ShaheenKhadiga S IbrahimHeba Mahdy-AbdallahMona Mohamed TahaSalwa F HafezPublished in: Archives of environmental & occupational health (2020)
The goal of the present study is to estimate the oxidative effects of AFB1 induced hepatotoxicity in furniture wood dust exposed workers. A cross-sectional comparative study was designed for comparing AFB1/albumin (AFB1/alb) levels and liver functions [alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP)], malondialdehyde (MDA), glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) in 88 furniture workers and 78 controls not occupationally exposed to wood dust. The AFB1/Alb, AST, ALT, MDA, and GPx were significantly higher; while, CAT significantly reduced in workers compared with controls. There was a significant correlation between AFB1/Alb and MDA level with the liver enzymes among both groups. CAT was inversely correlated with AFB1/Alb and the liver enzymes, and GPx was inversely correlated with AST in the workers. It was concluded that wood dust exposure is associated with raised serum levels of AFB1 and oxidative stress.
Keyphrases
- oxidative stress
- health risk
- health risk assessment
- human health
- breast cancer cells
- polycyclic aromatic hydrocarbons
- drug induced
- diabetic rats
- hydrogen peroxide
- risk assessment
- cell proliferation
- climate change
- cell cycle arrest
- endoplasmic reticulum stress
- amyotrophic lateral sclerosis
- endothelial cells
- induced apoptosis