Magnetic DNA Nanogels for Targeting Delivery and Multistimuli-Triggered Release of Anticancer Drugs.

DNA polymeric materials possess many unique properties such as programmable molecular sequences and excellent biocompatibility and have demonstrated a high potential in an assortment of biomedical applications. Herein, a magnetic DNA nanogel is constructed, aiming at the applications of targeting drug delivery and triggered drug release. Centering on magnetic nanoparticles, a DNA nanogel layer is synthesized via rolling circle amplification, which equips abundant sites for the loading of anticancer drugs. Guided by an external magnetic field, the magnetic DNA nanogel can target tumor cells efficiently. Moreover, DNA nanogel is responsive to multistimuli including temperature, pH, and nuclease, enabling a controlled release of anticancer drugs. Our system achieves magnet-controlled delivery and stimuli-triggered drug release and provides a new strategy for the development of precision medicine.