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Tissue engineering in otology: a review of achievements.

Reza KaboodkhaniDavood MehrabaniArmaghan MoghaddamIman SalahshooriHossein Ali Khonakdar
Published in: Journal of biomaterials science. Polymer edition (2024)
Tissue engineering application in otology spans a distance from the pinna to auditory nerve covered with specialized tissues and functions such as sense of hearing and aesthetics. It holds the potential to address the barriers of lack of donor tissue, poor tissue match, and transplant rejection through provision of new and healthy tissues similar to the host and possesses the capacity to renew, to regenerate, and to repair in-vivo and was shown to be a bypasses for any need to immunosuppression. This review aims to investigate the application of tissue engineering in otology and to evaluate the achievements and challenges in external, middle and inner ear sections. Since gaining the recent knowledge and training on use of different scaffolds is essential for otology specialists and who look for the recovery of ear function and aesthetics of patients, it is shown in this review how utilizing tissue engineering and cell transplantation, regenerative medicine can provide advancements in hearing and ear aesthetics to fit different patients' needs.
Keyphrases
  • tissue engineering
  • end stage renal disease
  • newly diagnosed
  • ejection fraction
  • gene expression
  • prognostic factors
  • healthcare
  • stem cells
  • hearing loss
  • working memory
  • climate change