AgNTf 2 -Catalyzed Regioselective C-H Alkenylation of N,N -Dialkylanilines with Ynamides.

Regioselective C-H alkenylation of N,N -dialkylanilines with ynamides was developed using AgNTf 2 as a catalyst. This approach represents a facile hydroarylation of ynamides, allowing for the introduction of an alkenyl group exclusively at the para position of aniline derivatives. As a result, a series of 4-alkenyl N,N -dialkylanilines were synthesized with excellent regioselectivities.