Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations With Atrial Fibrillation.

Yunju YangTraci M BartzMichael R Brown Xiuqing GuoNuno R ZilhaoStella Trompet Stefan Weiss Jie Yao Jennifer A Brody Christopher R Defilippi Ron C Hoogeveen Henry J Lin Vilmundur G Gudnason Christie M Ballantyne Marcus Dörr Johan Wouter JukemaAstrid PetersmannBruce M Psaty Jerome I RotterEric BoerwinkleMyriam Fornage Goo Jun Bing Yu

Published in: Circulation. Genomic and precision medicine (2021)

We identified a novel genetic locus associated with hs-cTnT in a multiethnic population and found that genetically regulated troponin levels were associated with atrial fibrillation.

Keyphrases

atrial fibrillation
oral anticoagulants
catheter ablation
left atrial
left atrial appendage
genome wide
direct oral anticoagulants
heart failure
copy number
percutaneous coronary intervention
transcription factor
gene expression