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Bivalent COVID-19 mRNA booster vaccination (BA.1 or BA.4/BA.5) increases neutralization of matched Omicron variants.

David Niklas SpringerMichael BauerIris MeditsJeremy V CampStephan W AberleClemens BurtscherEva HöltlLukas WeseslindtnerKarin StiasnyJudith Helene Aberle
Published in: NPJ vaccines (2023)
We report SARS-CoV-2 neutralizing antibody titers in sera of triple-vaccinated individuals who received a booster dose of an original monovalent or a bivalent BA.1- or BA.4/BA.5-adapted vaccine or had a breakthrough infection with Omicron variants BA.1, BA.2 or BA.4/BA.5. A bivalent BA.4/BA.5 booster or Omicron-breakthrough infection induced increased Omicron-neutralization titers compared with the monovalent booster. The XBB.1.5 variant effectively evaded neutralizing-antibody responses elicited by current vaccines and/or infection with previous variants.
Keyphrases
  • sars cov
  • coronavirus disease
  • copy number
  • gene expression
  • oxidative stress
  • dna methylation