Risk of radionecrosis in HER2-positive breast cancer with brain metastasis receiving trastuzumab emtansine (T-DM1) and brain stereotactic radiosurgery.

Seok-Joo ChunKyubo KimYong Bae KimSun Ha PaekKyung-Hun LeeJin-Ho SongWon Il JangTae Hyun KimViola SalvestriniIcro MeattiniLorenzo LiviKyung Hwan Shin

Published in: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (2024)

An increased risk of radionecrosis was observed in patients receiving T-DM1 with brain SRS. Further research is needed to better understand the optimal sequence and interval for administering T-DM1 and SRS.

Keyphrases

positive breast cancer
resting state
white matter
functional connectivity
cerebral ischemia
glycemic control
type diabetes
epidermal growth factor receptor
multiple sclerosis
brain injury
amino acid
tyrosine kinase