A Cellulose/Chitosan Dual-Crosslinked Multifunctional and Resilient Hydrogel for Emergent Open Wound Management.

Adhesive hydrogel holds huge potentials in biomedical applications, such as hemostasis and emergent wound management during outpatient treatment or surgery. However, most adhesive hydrogels underperform to offer robust adhesions on the wet tissue, increasing the risk of hemorrhage and reducing the fault tolerance of surgery. To address this issue, we develop a polysaccharide-based bioadhesive hydrogel tape (ACAN) consisting of dual-crosslinking of allyl cellulose (AC) and carboxymethyl chitosan (CMCS). The hygroscopicity of AC and CMCS networks enable ACAN to remove interfacial water from the tissue surface and initialize a physical crosslink instantly. Subsequently, covalent crosslinks are developed with amine moieties to sustain long-term and robust adhesion. The dual-crosslinked ACAN also has good cytocompatibility with controllable mechanical properties matching to the tissue, where the addition of CMCS provides remarkable antibacterial properties and hemostatic capability. Moreover, compared with commercially available 3 M film, ACAN provides an ultrafast wound healing on tissue. The ACAN hybrid hydrogels have advantages such as biocompatibility and antibacterial, hemostatic, and wound healing properties, shedding new light on first aid tape design and advancing the cellulose-based materials technology for high performance biomedical applications. This article is protected by copyright. All rights reserved.