An evaluation of the amyloid cascade model using in vivo positron emission tomographic imaging.
Fumihiko YasunoAkinori NakamuraTakashi KatoKaori IwataTakashi SakuraiYutaka ArahataYukihiko WashimiHideyuki HattoriKengo ItoPublished in: Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society (2020)
Our in vivo evaluation of positron emission tomographic and magnetic resonance imaging data supported the amyloid cascade hypothesis. In addition, it indicated that Aβ not only accelerates tau aggregation/neuroinflammation but promotes its toxicity. Our findings showed the importance of understanding the role and therapeutic potential of the interaction between amyloid and tau aggregation/neuroinflammation in Alzheimer's disease.
Keyphrases
- magnetic resonance imaging
- traumatic brain injury
- lipopolysaccharide induced
- lps induced
- cerebrospinal fluid
- cognitive impairment
- high resolution
- cerebral ischemia
- computed tomography
- electronic health record
- cognitive decline
- oxidative stress
- cone beam
- big data
- inflammatory response
- machine learning
- contrast enhanced
- mass spectrometry
- photodynamic therapy
- solid state
- subarachnoid hemorrhage